Facile Cu(ii)-mediated conjugation of thioesters and thioacids to peptides and proteins under mild conditions.

@article{Sun2018FacileCC,
  title={Facile Cu(ii)-mediated conjugation of thioesters and thioacids to peptides and proteins under mild conditions.},
  author={Yao Sun and Zhenbin Lyu and Zhiqiang Wang and Xiaodong Zeng and Hui Zhou and Fuchun Xu and Ziyang Chen and Yuling Xu and Ping Xu and Xuechuan Hong},
  journal={Organic & biomolecular chemistry},
  year={2018},
  volume={16 19},
  pages={3610-3614}
}
The bioconjugation of peptide derivatives such as polypeptides, peptide-based probes and proteins is a vibrant area in many scientific fields. However, reports on metal-mediated chemical methods towards native peptides especially non-engineering protein modification under mild conditions are still limited. Herein, we describe a novel Cu(ii)-mediated… CONTINUE READING