Facially selective and regioselective carbometalation of cyclopropenes by aryl Grignard reagents.

  title={Facially selective and regioselective carbometalation of cyclopropenes by aryl Grignard reagents.},
  author={Ni Yan and Xiaozhong Liu and Joseph M. Fox},
  journal={The Journal of organic chemistry},
  volume={73 2},
Described is a Cu-catalyzed methodology for adding aryl Grignard reagents to 3-hydroxymethylcyclopropene derivatives with high regio- and diastereoselectivity. The cyclopropylmetals can be trapped with a variety of electrophiles to generate highly substituted cyclopropanes. 
36 Citations
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