Facial contact dermatitis due to spironolactone in an anti‐acne cream

@article{Vincenzi1993FacialCD,
  title={Facial contact dermatitis due to spironolactone in an anti‐acne cream},
  author={Colombina Vincenzi and Pompilio Trevist and Paolo Maria Farina and Caterina Stinchi and Antonella Tosti},
  journal={Contact Dermatitis},
  year={1993},
  volume={29}
}
Topical spironolactone has recently been introduced in Italy for the treatment of acne, on account of its antiandrogenic effects. Spironolactone is an aldosterone antagonist widely used systemically for disorders such as essential hypertension, primary hyperaldosteronism and edema associated with congestive heart failure or ascites of hepatic cirrhosis (1). Oral administration of spironolactone is frequently responsible for side-effects that are mostly due to its anti-androgenic action… Expand
9 Citations
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androgenic actions of testosterone, by occupying its cytoplasmic and nuclear receptors in the target tissues. As well as its original use as a potassium-saving diuretic, it has therefore also beenExpand
Allergic contact dermatitis from spironolactone
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Tests with the constituents of the cream confirmed an allergic contact reaction to spironolactone, and a 30-year-old woman presented with acute facial dermatitis after the use of Spiroderm® cream for acne vulgaris. Expand
Drug-induced eosinophilia and multisystemic failure with positive patch-test reaction to spironolactone: DRESS syndrome.
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The case of a 58-year-old man who suffered from a generalized and intolerable itching one month after starting treatment with colchicine, amiodarone, perindopril, allopurinol and spironolactone, and the diagnosis of drug rash with eosinophilia and systemic symptoms (DRESS) induced by spironlactone was made, this is the first report of DRESS due to spironOLactone. Expand
Allergic contact dermatitis from red sandalwood (Pterocarpus santalinus)
5. Cunliffe W J, Burke B. Benzoyl peroxide: lack of sensitization. Acta Dermato-venereologica 1983: 62: 458-459. 6. BalatoN, Lembo G, Nappa P, Ayala F. Benzoyl peroxide reactions in acne patients.Expand
Allergic contact dermatitis due to dibromodicyanobutane in cosmetics
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Allergic contact dermatitis from sesquiterpene lactone in lnula viscosa Aiton and immunologic specificity of Compositae, liverworts and lichens. Expand
Acne and allergic contact dermatitis
TLDR
204 patients, under treatment for at least 2 months, entered this study, and a special series of allergens was used for patch testing and repeated open application tests (ROAT) were done with each component of the topical product. Expand
Occupational dermatitis in hairdressers
TLDR
Screening for corticosteroid contact hypersensitivity in patients with contact dermatitis and delayed systemic allergic reactions to cortiosteroids is recommended. Expand

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A cutaneous eruption with clinical and histopathological features of lichen planus that the authors consider to be caused by the antihypertensive-diuretic spironolactone is reported, which is suspected as a cause of the lichen-planuslike eruption. Expand
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