Facial contact dermatitis due to spironolactone in an anti‐acne cream

  title={Facial contact dermatitis due to spironolactone in an anti‐acne cream},
  author={Colombina Vincenzi and Pompilio Trevist and Paolo Maria Farina and Caterina Stinchi and Antonella Tosti},
  journal={Contact Dermatitis},
Topical spironolactone has recently been introduced in Italy for the treatment of acne, on account of its antiandrogenic effects. Spironolactone is an aldosterone antagonist widely used systemically for disorders such as essential hypertension, primary hyperaldosteronism and edema associated with congestive heart failure or ascites of hepatic cirrhosis (1). Oral administration of spironolactone is frequently responsible for side-effects that are mostly due to its anti-androgenic action… Expand
9 Citations
Allergic contact dermatitis from spironolactone
Side-effects of spironolactone, a steroid derived from 17 -spiro lactone, include decreased libido, impotence, gynecomastia and hirsutism. Expand
Allergic contact dermatitis from propylene glycol in Zovirax cream
androgenic actions of testosterone, by occupying its cytoplasmic and nuclear receptors in the target tissues. As well as its original use as a potassium-saving diuretic, it has therefore also beenExpand
Allergic contact dermatitis from spironolactone
Tests with the constituents of the cream confirmed an allergic contact reaction to spironolactone, and a 30-year-old woman presented with acute facial dermatitis after the use of Spiroderm® cream for acne vulgaris. Expand
Drug-induced eosinophilia and multisystemic failure with positive patch-test reaction to spironolactone: DRESS syndrome.
The case of a 58-year-old man who suffered from a generalized and intolerable itching one month after starting treatment with colchicine, amiodarone, perindopril, allopurinol and spironolactone, and the diagnosis of drug rash with eosinophilia and systemic symptoms (DRESS) induced by spironlactone was made, this is the first report of DRESS due to spironOLactone. Expand
Allergic contact dermatitis from red sandalwood (Pterocarpus santalinus)
5. Cunliffe W J, Burke B. Benzoyl peroxide: lack of sensitization. Acta Dermato-venereologica 1983: 62: 458-459. 6. BalatoN, Lembo G, Nappa P, Ayala F. Benzoyl peroxide reactions in acne patients.Expand
Allergic contact dermatitis due to dibromodicyanobutane in cosmetics
Allergic contact dermatitis from sesquiterpene lactone in lnula viscosa Aiton and immunologic specificity of Compositae, liverworts and lichens. Expand
Acne and allergic contact dermatitis
204 patients, under treatment for at least 2 months, entered this study, and a special series of allergens was used for patch testing and repeated open application tests (ROAT) were done with each component of the topical product. Expand
Occupational dermatitis in hairdressers
Screening for corticosteroid contact hypersensitivity in patients with contact dermatitis and delayed systemic allergic reactions to cortiosteroids is recommended. Expand


Contact dermatitis from spironolactone
Contact sensitisation to spironolactone has not been previously reported and is considered to be caused by this antihypertensive-diuretic drug. Expand
Spironolactone-induced lichen planus.
A cutaneous eruption with clinical and histopathological features of lichen planus that the authors consider to be caused by the antihypertensive-diuretic spironolactone is reported, which is suspected as a cause of the lichen-planuslike eruption. Expand
Cutaneous reaction to spironolactone resembling lupus erythematosus.
The character and distribution of the rash after spironolactone administration was identical to the previous lesions, which is good evidence that it and not chlorothiazide was responsible for the rash. Expand
Topical antiandrogens. What use in dermatology?
  • A. Lucky
  • Medicine
  • Archives of dermatology
  • 1985
The interaction between androgenic hormones and the skin has been a fascinating area of research that has tantalized dermatologists for several decades, and an understanding of the response of the skin and its appendages to circulating hormones requires innovative research. Expand
Tolerance of spironolactone
A survey of 54 patients taking spironolactone for hirsutes or acne showed that side‐effects occurred in 91%; in 80% of patients, these were related to the anti‐androgenic mechanism of the drugExpand
Lack of endocrine systemic side effects after topical application of spironolactone in man
Topically administered, spironolactone appears to have only a local skin impregnation and plasma canrenone levels were undetectable during the 72 hours of topical treatment. Expand
Spironolactone in dermatologic therapy.
  • J. C. Shaw
  • Medicine
  • Journal of the American Academy of Dermatology
  • 1991
The use of spironolactone as an antiandrogen in dermatologic therapy is reviewed, the endocrinologic effects, pharmacology, dermatologic uses, and side effects are discussed, and guidelines for its use are provided. Expand
Antiandrogenic effects of topically applied spironolactone on the hamster flank organ.
Topically administered spironolactone appears to have only local antiandrogenic effects, as indicated by the lack of changes in the untreated contralateral flank organs and in the weights of seminal vesicles. Expand
Spironolactone in dermatologiec therapy
  • JAm Acad Dermatol
  • 1991