Fabry disease in mice is associated with age-dependent susceptibility to vascular thrombosis.

@article{Eitzman2003FabryDI,
  title={Fabry disease in mice is associated with age-dependent susceptibility to vascular thrombosis.},
  author={Daniel T. Eitzman and Peter F. Bodary and Yuechun Shen and Christian G Khairallah and S. Roger Wild and Akira Abe and Jacqueline N Shaffer-Hartman and James A. Shayman},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2003},
  volume={14 2},
  pages={298-302}
}
Fabry disease is an X-linked lysosomal storage disorder due to deficiency of alpha-galactosidase A (GLA) activity that results in the widespread accumulation of neutral glycosphingolipids. Renal failure, neuropathy, premature myocardial infarction, and stroke occur in patients with this condition primarily due to deposition of glycosphingolipids in vascular endothelial cells. The clinical consequences of Fabry disease suggest that vascular thrombosis may play a prominent role in the… CONTINUE READING

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