Fabrication of elastin-like polypeptide nanoparticles for drug delivery by electrospraying.

@article{Wu2009FabricationOE,
  title={Fabrication of elastin-like polypeptide nanoparticles for drug delivery by electrospraying.},
  author={Yiquan Wu and J Andrew MacKay and Jonathan R. McDaniel and Ashutosh Chilkoti and Robert L. Clark},
  journal={Biomacromolecules},
  year={2009},
  volume={10 1},
  pages={19-24}
}
The development of environmentally responsive drug carriers requires new methods for assembling stimuli-responsive nanoparticulates. This communication describes a novel application of electrospray to construct bioresponsive peptide-based particulates, which can encapsulate drugs. These particles are composed from genetically engineered elastin-like polypeptides (ELPs), a biodegradable, biocompatible, and bioresponsive polymer. To generate nanoparticles (300-400 nm in diameter), ELPs and drugs… CONTINUE READING
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