Fabrication of biodegradable polymer scaffolds to engineer trabecular bone.

@article{Thomson1995FabricationOB,
  title={Fabrication of biodegradable polymer scaffolds to engineer trabecular bone.},
  author={R. Y. Thomson and Michael J. Yaszemski and John Michael Powers and Antonios G Mikos},
  journal={Journal of biomaterials science. Polymer edition},
  year={1995},
  volume={7 1},
  pages={23-38}
}
We present a novel method for manufacturing three-dimensional, biodegradable poly(DL-lactic-co-glycolic acid) (PLGA) foam scaffolds for use in bone regeneration. The technique involves the formation of a composite material consisting of gelatin microspheres surrounded by a PLGA matrix. The gelatin microspheres are leached out leaving an open-cell foam with a pore size and morphology defined by the gelatin microspheres. The foam porosity can be controlled by altering the volume fraction of… CONTINUE READING

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