Fabrication of Hyperbranched Block-Statistical Copolymer-Based Prodrug with Dual Sensitivities for Controlled Release.
@article{Zheng2017FabricationOH, title={Fabrication of Hyperbranched Block-Statistical Copolymer-Based Prodrug with Dual Sensitivities for Controlled Release.}, author={Luping Zheng and Yunfei Wang and Xianshuo Zhang and Liwei Ma and Baoyan Wang and Xiangling Ji and Hua Wei}, journal={Bioconjugate chemistry}, year={2017}, volume={29 1}, pages={ 190-202 } }
Dendrimer with hyperbranched structure and multivalent surface is regarded as one of the most promising candidates close to the ideal drug delivery systems, but the clinical translation and scale-up production of dendrimer has been hampered significantly by the synthetic difficulties. Therefore, there is considerable scope for the development of novel hyperbranched polymer that can not only address the drawbacks of dendrimer but maintain its advantages. The reversible addition-fragmentation…
21 Citations
One-Pot Synthesis of Dual-Responsive Hyperbranched Polymeric Prodrugs Using an All-in-One Chain Transfer Monomer.
- Chemistry, BiologyACS macro letters
- 2018
One-pot preparation of dual-responsive hyperbranched polymeric prodrugs (DRHPPs) using an all-in-one chain transfer monomer that integrates a drug molecule with both acidic pH- and reduction-sensitive links offered a highly promising platform for efficient anticancer drug delivery.
Triple Functional AB2 Unit-Modulated Facile Preparation of Bioreducible Hyperbranched Copolymers.
- Materials Science, BiologyACS biomaterials science & engineering
- 2020
A triple functional AB2 unit, A-SS-B2 chain transfer agent (AB2 CTA), that integrates the merits of both multifunctional agents and highly reactive ABx units was designed and synthesized successfully to include a disulfide bond for reduction-triggered polymer degradation toward promoted intracellular release of encapsulated cargoes.
Fabrication of Reduction-Sensitive Amphiphilic Cyclic Brush Copolymer for Controlled Drug Release.
- Biology, Materials ScienceMacromolecular bioscience
- 2018
The overall results demonstrate the reducible cyclic brush copolymers developed herein provides an elegant solution to the tradeoff between extracellular stability and intracellular high therapeutic efficacy toward efficient anticancer drug delivery.
Biomedical application of hyperbranched polymers: Recent Advances and challenges
- Materials Science
- 2021
Fabrication of theranostic amphiphilic conjugated bottlebrush copolymers with alternating heterografts for cell imaging and anticancer drug delivery
- Materials Science, Chemistry
- 2018
This study presents the first example of PF-backboned bb copolymers with alternating heterobrushes for cancer theranostics, by integrated state-of-the-art polymer chemistry techniques including Suzuki-coupling polycondensation, ring-opening polymerization, click reaction and atom transfer radical polymerization (ATRP).
Long-Chain Hyperbranched Polymers: Synthesis, Properties, and Applications.
- Materials ScienceMacromolecular rapid communications
- 2018
A comprehensive summary of the research progress of LCHBPs is presented, with a particular focus on their synthetic strategies, unique properties, and potential applications.
Micelles with cyclic poly(ε-caprolactone) moieties: greater stability, larger drug loading capacity, and slower degradation property for controlled drug release.
- Materials Science, BiologyLangmuir : the ACS journal of surfaces and colloids
- 2019
The topological effect of a hydrophobic moiety on the properties of the self-assembled micelles is uncovered, and a complementary alternative to enhance the micelle stability by introducing a cyclic hydrophilic segment is developed.
Synthesis of cyclic graft polymeric prodrugs with heterogeneous grafts of hydrophilic OEG and reducibly conjugated CPT for controlled release.
- Biology, ChemistryBiomaterials science
- 2020
Cg-prodrug-based micelles exhibited greater in vitro cytotoxicity against cancer cells despite the lower drug loading content than the bg-based analogues, which results primarily from the faster reduction-triggered degradation and drug release as well as the greater cellular uptake efficiency of the former micelle prodrugs.
Branched and Dendritic Polymer Architectures: Functional Nanomaterials for Therapeutic Delivery
- BiologyAdvanced Functional Materials
- 2019
The present review describes and compares different branched polymer architectures and their application in therapeutic delivery in a simple and easy‐to‐understand way, with the aim of appealing to a multidisciplinary audience.
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