Fabrication of Hyperbranched Block-Statistical Copolymer-Based Prodrug with Dual Sensitivities for Controlled Release.

  title={Fabrication of Hyperbranched Block-Statistical Copolymer-Based Prodrug with Dual Sensitivities for Controlled Release.},
  author={Luping Zheng and Yunfei Wang and Xianshuo Zhang and Liwei Ma and Baoyan Wang and Xiangling Ji and Hua Wei},
  journal={Bioconjugate chemistry},
  volume={29 1},
Dendrimer with hyperbranched structure and multivalent surface is regarded as one of the most promising candidates close to the ideal drug delivery systems, but the clinical translation and scale-up production of dendrimer has been hampered significantly by the synthetic difficulties. Therefore, there is considerable scope for the development of novel hyperbranched polymer that can not only address the drawbacks of dendrimer but maintain its advantages. The reversible addition-fragmentation… 
21 Citations

One-Pot Synthesis of Dual-Responsive Hyperbranched Polymeric Prodrugs Using an All-in-One Chain Transfer Monomer

One-pot preparation of dual-responsive hyperbranched polymeric prodrugs (DRHPPs) using an all-in-one chain transfer monomer that integrates a drug molecule with both acidic pH- and reduction-sensitive links offered a highly promising platform for efficient anticancer drug delivery.

Triple Functional AB2 Unit-Modulated Facile Preparation of Bioreducible Hyperbranched Copolymers.

A triple functional AB2 unit, A-SS-B2 chain transfer agent (AB2 CTA), that integrates the merits of both multifunctional agents and highly reactive ABx units was designed and synthesized successfully to include a disulfide bond for reduction-triggered polymer degradation toward promoted intracellular release of encapsulated cargoes.

Fabrication of Reduction-Sensitive Amphiphilic Cyclic Brush Copolymer for Controlled Drug Release.

The overall results demonstrate the reducible cyclic brush copolymers developed herein provides an elegant solution to the tradeoff between extracellular stability and intracellular high therapeutic efficacy toward efficient anticancer drug delivery.

Fabrication of theranostic amphiphilic conjugated bottlebrush copolymers with alternating heterografts for cell imaging and anticancer drug delivery

This study presents the first example of PF-backboned bb copolymers with alternating heterobrushes for cancer theranostics, by integrated state-of-the-art polymer chemistry techniques including Suzuki-coupling polycondensation, ring-opening polymerization, click reaction and atom transfer radical polymerization (ATRP).

Long-Chain Hyperbranched Polymers: Synthesis, Properties, and Applications.

A comprehensive summary of the research progress of LCHBPs is presented, with a particular focus on their synthetic strategies, unique properties, and potential applications.

Micelles with cyclic poly(ε-caprolactone) moieties: greater stability, larger drug loading capacity, and slower degradation property for controlled drug release.

The topological effect of a hydrophobic moiety on the properties of the self-assembled micelles is uncovered, and a complementary alternative to enhance the micelle stability by introducing a cyclic hydrophilic segment is developed.

Synthesis of cyclic graft polymeric prodrugs with heterogeneous grafts of hydrophilic OEG and reducibly conjugated CPT for controlled release.

Cg-prodrug-based micelles exhibited greater in vitro cytotoxicity against cancer cells despite the lower drug loading content than the bg-based analogues, which results primarily from the faster reduction-triggered degradation and drug release as well as the greater cellular uptake efficiency of the former micelle prodrugs.

Branched and Dendritic Polymer Architectures: Functional Nanomaterials for Therapeutic Delivery

The present review describes and compares different branched polymer architectures and their application in therapeutic delivery in a simple and easy‐to‐understand way, with the aim of appealing to a multidisciplinary audience.

Glutathione Triggered Cascade Degradation of an Amphiphilic Poly(disulfide)-Drug Conjugate and Targeted Release.

A bioreducible poly(disulfide)-derived amphiphilic block copolymer-drug conjugate (loading content 31%) was synthesized by post-polymerization modification. It shows redox-responsive polymersome



Water-Soluble and Clickable Segmented Hyperbranched Polymers for Multifunctionalization and Novel Architecture Construction

A series of novel and narrowly polydispersed regular chain-segmented hyperbranched poly(tertiary amino methacrylate)s (HPTAM)s with hydrophilic core and hydrophobic shell were synthesized via the

Hyperbranched Glycopolymer Grafted Microspheres

The synthesis and characterization of acetylglucosamine-displaying microspheres consisting of poly(divinylbenzene) (PDVB) cores onto which chains of linear and branched glycopolymer chains were

pH-sensitive drug release of star-shaped micelles with OEG brush corona

A new insight is believed to be provided into the structure–bioproperties relationship of star-shaped polymers, thus should be useful for the future design and development of novel star- shaped polymers for controlled drug delivery.

The dendrimer paradox--high medical expectations but poor clinical translation.

  • S. Svenson
  • Chemistry, Biology
    Chemical Society reviews
  • 2015
This review was written with the intention to critically evaluate the status of dendrimers as drug carriers and find answers as to why this class of compounds has not translated into the clinic

Facile synthesis of RGD-conjugated unimolecular micelles based on a polyester dendrimer for targeting drug delivery.

Results indicated that as-developed unimolecular micelles are promising candidates as tumor-targeted drug delivery nanocarriers.

Synthesis and Characterization of Surface-Grafted Hyperbranched Glycomethacrylates

Hyperbranched glycopolymers were grafted from a silicon wafer with a covalently attached initiator layer of α-bromoester fragments using self-condensing vinyl copolymerization (SCVCP) of the

Synthesis of Hyperbranched Polyacrylates by a Chloroinimer Approach

(2-Chloro-2-alkoxycarbonyl)ethyl acrylates with methyl, dodecyl, perfluoroalkyl, siloxane, oligooxyethylene, and mesogenic ester substituents were synthesized as inimers for self-condensing vinyl