Fabrication of 6-gingerol, doxorubicin and alginate hydroxyapatite into a bio-compatible formulation: enhanced anti-proliferative effect on breast and liver cancer cells

@article{Manatunga2018FabricationO6,
  title={Fabrication of 6-gingerol, doxorubicin and alginate hydroxyapatite into a bio-compatible formulation: enhanced anti-proliferative effect on breast and liver cancer cells},
  author={Danushika C. Manatunga and Rohini M de Silva and K M Nalin de Silva and Dulharie T. Wijeratne and Gathsaurie Neelika Malavige and Gareth R Williams},
  journal={Chemistry Central Journal},
  year={2018},
  volume={12},
  pages={1-13}
}
Ample attention has been devoted to the construction of anti-cancer drug delivery systems with increased stability, and controlled and targeted delivery, minimizing toxic effects. In this study we have designed a magnetically attractive hydroxyapatite (m-HAP) based alginate polymer bound nanocarrier to perform targeted, controlled and pH sensitive drug release of 6-gingerol, doxorubicin, and their combination, preferably at low pH environments (pH 5.3). They have exhibited higher encapsulation… CONTINUE READING
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