Fabrication and evaluation of captopril modified-release oral formulation.

  title={Fabrication and evaluation of captopril modified-release oral formulation.},
  author={Mukesh C. Gohel and Stavan Arunkumar Nagori},
  journal={Pharmaceutical development and technology},
  volume={14 6},
The present research was directed towards fabrication of modified-release captopril oral formulation. A 3(2) full factorial design was employed for optimization using captopril to Compritol ATO 888 ratio (X1) and extragranular fraction of ethyl cellulose (X2) as independent variables. The percentage drug released in 1 h (Y1) and the time required to release 80% of the drug (Y2) were selected as dependent variables. Eutectic blend of camphor and menthol was used as a solvent to facilitate the… CONTINUE READING

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