Fabrication and characterization of chitosan/gelatin porous scaffolds with predefined internal microstructures

@article{Jiankang2007FabricationAC,
  title={Fabrication and characterization of chitosan/gelatin porous scaffolds with predefined internal microstructures},
  author={He Jian-kang and L. C. Dichen and Liu Yaxiong and Yao Bo and Lu Bingheng and Lian Qin},
  journal={Polymer},
  year={2007},
  volume={48},
  pages={4578-4588}
}
The fabrication process for a novel three-dimensional (3D) chitosan/gelatin scaffold with predefined multilevel internal architectures and highly porous structures is presented combining solid freeform fabrication (SFF), microreplication and lyophilization techniques. The computer model of the scaffold is designed with biological data such as branching angle in liver vascular cast incorporated. Stereolithography (SL), known as a SFF technique, is utilized to build the resin mould, based on… Expand
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References

SHOWING 1-10 OF 55 REFERENCES
Porous chitosan scaffolds for tissue engineering.
TLDR
The methods and structures described here provide a starting point for the design and fabrication of a family of polysaccharide based scaffold materials with potentially broad applicability in several tissue-relevant geometries. Expand
Three-dimensional aqueous-derived biomaterial scaffolds from silk fibroin.
TLDR
These new silk-based three-dimensional matrices provide useful properties as biomaterial matrices due to the all-aqueous mode of preparation, control of pore size, connectivity of pores, degradability and useful mechanical features. Expand
Mechanical properties and cell cultural response of polycaprolactone scaffolds designed and fabricated via fused deposition modeling.
TLDR
FDM allows the design and fabrication of highly reproducible bioresorbable 3D scaffolds with a fully interconnected pore network and shows that fibroblasts and osteoblast-like cells can proliferate, differentiate, and produce a cellular tissue in an entirely interconnected 3D polycaprolactone matrix. Expand
Structure and properties of bilayer chitosan-gelatin scaffolds.
TLDR
The results suggested that the porosity and pore size of the scaffolds could be modulated with thermodynamic and kinetic parameters of ice formation and can be utilized as a promising matrix for tissue engineering. Expand
Porous 3-D scaffolds from regenerated silk fibroin.
TLDR
Three fabrication techniques were used to form porous three-dimensional silk biomaterial matrixes and the results suggest that silk-based 3D matrixes can be formed for utility in biomaterial applications. Expand
Poly(alpha-hydroxyl acids)/hydroxyapatite porous composites for bone-tissue engineering. I. Preparation and morphology.
  • R. Zhang, P. Ma
  • Materials Science, Medicine
  • Journal of biomedical materials research
  • 1999
TLDR
The preparation and morphologies of three-dimensional porous composites from poly(L-lactic acid) (PLLA) or poly(D,L- lactic acid-co-glycolic Acid) (PLGA) solution and hydroxyapatite (HAP) and composite foams showed a significant improvement in mechanical properties over pure polymer foams. Expand
Fabrication of microstructures in photosensitive biodegradable polymers for tissue engineering applications.
TLDR
Combining the MEMS technology and biology requirements for tissue engineering, the fabrication processes of microstructured chambers and microchannels made in biodegradable photosensitive polymers are presented and the possibility to use the present photosensitive polymer as microfluidic supports for biodesgradable bioreactors for implantation applications is suggested. Expand
Three-dimensional fibroin/collagen scaffolds derived from aqueous solution and the use for HepG2 culture
Abstract Although three-dimensional fibroin scaffolds have been prepared with freeze–drying method, these scaffolds still cannot meet the requirements of tissue engineering. In this article, a newExpand
Study of novel chitosan-gelatin artificial skin in vitro.
TLDR
The data from this study suggest that chitosan-gelatin scaffolds are suitable for skin tissue engineering goals. Expand
Novel design of a chitosan-collagen scaffold for hepatocyte implantation
  • H. J. Khamna, M. Klein, H. Matthew
  • Materials Science
  • Proceedings of the 22nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society (Cat. No.00CH37143)
  • 2000
Implantation of a bioartificial liver, composed of a hepatocyte seeded scaffold, has the potential to offer new treatment options for liver diseases. One of the problems associated with hepatocyteExpand
...
1
2
3
4
5
...