Fabrication and characterization of a multiwell array SERS chip with biological applications.

@article{Abell2009FabricationAC,
  title={Fabrication and characterization of a multiwell array SERS chip with biological applications.},
  author={Justin L. Abell and Jeremy D. Driskell and Richard A. Dluhy and Ralph A Tripp and Yikai Zhao},
  journal={Biosensors & bioelectronics},
  year={2009},
  volume={24 12},
  pages={
          3663-70
        }
}
Uniform, large surface area substrates for surface-enhanced Raman spectroscopy (SERS) are fabricated by oblique angle deposition. The SERS-active substrates are patterned by a polymer-molding technique to provide a uniform array for high throughput biosensing and multiplexing. Using a conventional SERS-active molecule, 1,2-di(4-pyridyl)ethylene (BPE) >or=98%, we show that this device provides a uniform Raman signal enhancement from well to well with a detection limit of at least 10(-8)M of the… CONTINUE READING
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