Fabrication and Functionalization of 3D Printed Polydimethylsiloxane‐Based Microfluidic Devices Obtained through Digital Light Processing

  title={Fabrication and Functionalization of 3D Printed Polydimethylsiloxane‐Based Microfluidic Devices Obtained through Digital Light Processing},
  author={Gustavo Gonz{\'a}lez and Annalisa Chiappone and Kurt Dietliker and Candido Fabrizio Pirri and Ignazio Roppolo},
  journal={Advanced Materials Technologies},
This work reports the preparation and 3D printing of a custom‐made photopolymer based on acrylate‐polydimethylsiloxane (PDMS), for the fabrication of complex‐shaped 3D printed microfluidic chips. By selecting and combining the proper materials during the preparation of the resins along with the freedom of design of light‐based 3D printers, 3D microfluidic PDMS‐like chips are obtained with excellent optical features, high chemical stability, and good mechanical properties. Furthermore, taking… 
Materials Testing for the Development of Biocompatible Devices through Vat-Polymerization 3D Printing
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Hydrophilic modification of SLA 3D printed droplet generators by photochemical grafting
Few droplet generators manufactured using desktop stereolithography 3D printers have been reported in the literature. Moreover, 3D printed microfluidic chips are typically hydrophobic, limiting their
Vat Photopolymerization 3D Printing of Advanced Soft Sensors and Actuators: From Architecture to Function
Fabrication and assembly of flexible sensors and soft actuators play important roles in improving the performance of wearable electronics and soft robots. Traditional manufacturing techniques have
3D Printing of PDMS-Like Polymer Nanocomposites with Enhanced Thermal Conductivity: Boron Nitride Based Photocuring System
This study demonstrates the possibility of forming 3D structures with enhanced thermal conductivity (k) by vat printing a silicone–acrylate based nanocomposite by boron nitride (BN) nanoparticles using a digital light processing system to form complex structures.
Flexible Materials for High-Resolution 3D Printing of Microfluidic Devices with Integrated Droplet Size Regulation
The library of functional resins for PμSL printing toward flexible materials with micrometer resolution is expanded and provides the basis for further exploration of these materials, e.g., as microstructured cell-culturing substrates with defined mechanics.
Recent Developments in 3D Printing of Droplet-Based Microfluidics
The advent of microfluidics, especially with the integration of droplet-based systems, has led to significant innovations and outstanding applications in many fields. While this field of study has
Conventional and emerging strategies for the fabrication and functionalization of PDMS-based microfluidic devices.
A wide range of functionalization techniques are provided rendering PDMS microchannels highly biocompatible for physical or covalent immobilization of various biological entities while preventing non-specific interactions.
Fabrication Methods for Microfluidic Devices: An Overview
Direct and replication approaches for manufacturing of polymer microfluidic devices, including mechanical, energy-assisted, and traditional micro-electromechanical systems (MEMS) processes, as well as mould fabrication approaches for curved surfaces are described.
Functional Dyes in Polymeric 3D Printing: Applications and Perspectives
Three-dimensional printing (3DP) is considered among the key-technologies for the next industrial revolution, with considerable effects on production processes, economy, and society. In this contex...
Low-cost and open-source strategies for chemical separations.


Desktop‐Stereolithography 3D‐Printing of a Poly(dimethylsiloxane)‐Based Material with Sylgard‐184 Properties
The 3DP-PDMS resin enables assembly-free, automated, digital manufacturing of PDMS, which should facilitate the prototyping of devices for microfluidics, organ-on-chip platforms, soft robotics, flexible electronics, and sensors, among others.
The upcoming 3D-printing revolution in microfluidics.
The salient features of PDMS molding with those of 3D-printing are compared and an overview of the critical barriers that have prevented the adoption of3D-printed systems by microfluidic developers are given, namely resolution, throughput, and resin biocompatibility.
Comparing Microfluidic Performance of Three-Dimensional (3D) Printing Platforms.
A direct experimental comparison of the three 3D printing technologies dominating microfluidics was conducted using a Y-junction micro fluidic device, the design of which was optimized for each printer: fused deposition molding (FDM), Polyjet, and digital light processing stereolithography (DLP-SLA).
Increasing the functionalities of 3D printed microchemical devices by single material, multimaterial, and print-pause-print 3D printing.
This review provides an overview on the ways in which 3D printing has been exploited to create and use fluidic devices with different functionality, which provides a basis for critical reflection on the current deficiencies and future opportunities for integration by3D printing.
Biotinylated Photopolymers for 3D-Printed Unibody Lab-on-a-Chip Optical Platforms.
The present work reports the first demonstration of straightforward fabrication of monolithic unibody lab-on-a-chip (ULOCs) integrating bioactive micrometric 3D scaffolds by means of multimaterial
Facile Preparation of Photocurable Siloxane Composite for 3D Printing
This study presents the development and successful 3D printing of siloxane composite. Complex structures are 3D printed using vector-scanning stereolithography apparatus. Siloxane oligomer and a
Photopolymer resins for luminescent three‐dimensional printing
Liquid resins based three-dimensional (3D) printing techniques such as stereolithography (SLA) and digital light processing (DLP) show higher resolution and accuracy than other printing techniques,
Polymeric 3D Printed Functional Microcantilevers for Biosensing Applications.
3D microfabrication techniques, material characterization, and biosensor development could be combined to obtain an engineered polymeric microcantilever with intrinsic functionalities, paving the way to a new class of mass-sensing microelectromechanical system devices with intrinsic properties.
3D Printing All‐Aromatic Polyimides using Mask‐Projection Stereolithography: Processing the Nonprocessable
This study demonstrates the unprecedented 3D printing of PMDA-ODA using mask-projection stereolithography, and the preparation of high-resolution 3D structures without sacrificing bulk material properties.
A 3D printed fluidic device that enables integrated features.
A reusable, high throughput, 3D printed fluidic device was created that enables flow and incorporates a membrane above a channel in order to study drug transport and affect cells and it is shown that mammalian cells cultured on this membrane can be affected by reagents flowing through the channels.