• Corpus ID: 108155548

Fabrication Of Miniature Drug Screening Platform Using Low Cost Bioprinting Technology

@inproceedings{Devora2010FabricationOM,
  title={Fabrication Of Miniature Drug Screening Platform Using Low Cost Bioprinting Technology},
  author={Rodriguez Devora and Jorge Iv{\'a}n},
  year={2010}
}

• Rodriguez Devora, J. Iván
• Published 2010
• Biology

by JORGE IVÁN RODRÍGUEZ DÉVORA In the pharmaceutical industry, new chemicals and substances are being tested to find appropriate compounds or mix for treating a specific disease. The demand for screening large compound collections against and increasing number of therapeutic targets has stimulated technology development in the areas of assay automation and miniaturization. Current methods for evaluating the reactions of cells use a volume in the range of microliters. We have developed a new and low-cost deposition method to fabricate miniature drug screening platform that can realistically and inexpensively evaluate biochemical reactions up to 4 substances per trial in a picoliter-scale volume. This paper describes the development of the controls for a deposition method (inkjet printing technology) which simultaneously place therapeutic drugs and cells onto target sites to fabricate cell/drug chips for drug screening application. Using a modified HP D5360 CD printer, droplets of GFP expressing Escherichia coli have been deposited in an agar coated coverslip chip as small repeatable volume of 180 picoliters per each colony dot, along with this bacteria it has been patterned different antibiotics in such a way that we evaluated the growth of the bacteria under antibiotics presence.