Fabricating large arrays of microwells with arbitrary dimensions and filling them using discontinuous dewetting.

@article{Jackman1998FabricatingLA,
  title={Fabricating large arrays of microwells with arbitrary dimensions and filling them using discontinuous dewetting.},
  author={Rebecca J. Jackman and David C. Duffy and Emanuele Ostuni and Nikolaos D. Willmore and George M Whitesides},
  journal={Analytical chemistry},
  year={1998},
  volume={70 11},
  pages={2280-7}
}
This paper describes the fabrication of large (up to 45 cm(2)) arrays of microwells, with volumes as small as ∼3 fL/well and densities as high as 10(7) wells/cm(2). These arrays of microwells are formed by casting an elastomer, poly(dimethylsiloxane) (PDMS), against "masters" prepared by photolithography; arrays of microwells in other polymers can be formed by using a master consisting of posts in PDMS. A straightforward technique, discontinuous dewetting, allows wells to be filled rapidly… CONTINUE READING
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