Fab1p PtdIns(3)P 5-Kinase Function Essential for Protein Sorting in the Multivesicular Body

@article{Odorizzi1998Fab1pP5,
  title={Fab1p PtdIns(3)P 5-Kinase Function Essential for Protein Sorting in the Multivesicular Body},
  author={Greg Odorizzi and Markus Babst and Scott D Emr},
  journal={Cell},
  year={1998},
  volume={95},
  pages={847-858}
}
Sorting of signal-transducing cell surface receptors within multivesicular bodies (MVBs) is required for their rapid down-regulation and degradation within lysosomes. Yeast mutants defective in late stages of transport to the vacuole/lysosome accumulate MVBs. We demonstrate that the membrane glycoprotein carboxypeptidase S and the G protein-coupled receptor Ste2p are targeted into the vacuole lumen, and this process requires a subset of VPS gene products essential for normal endosome function… CONTINUE READING
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