FZD8, a target of p53, promotes bone metastasis in prostate cancer by activating canonical Wnt/β-catenin signaling.

@article{Li2017FZD8AT,
  title={FZD8, a target of p53, promotes bone metastasis in prostate cancer by activating canonical Wnt/β-catenin signaling.},
  author={Qiji Li and Liping Ye and Xin Zhang and Min Wang and Chuyong Lin and Shuai Huang and Wei Guo and Yingrong Lai and Hong Du and Jun Li and Libing Song and Xinsheng Peng},
  journal={Cancer letters},
  year={2017},
  volume={402},
  pages={166-176}
}
Prostate cancer (PCa) is the second most frequently diagnosed cancer among men and exhibits a high propensity to metastasize to bone. Currently, bone metastasis remains incurable, and therapies are limited. A better understanding of the molecular mechanisms involved in PCa bone metastasis is needed to develop more effective therapeutics for this disease. Herein, we reported that among the FZD family, FZD8 was robustly upregulated in bone-metastastic PCa cell lines and tissues. High levels of… CONTINUE READING
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