FZD4 as a mediator of ERG oncogene-induced WNT signaling and epithelial-to-mesenchymal transition in human prostate cancer cells.

@article{Gupta2010FZD4AA,
  title={FZD4 as a mediator of ERG oncogene-induced WNT signaling and epithelial-to-mesenchymal transition in human prostate cancer cells.},
  author={Santosh Kumar Gupta and Kristiina Iljin and H Sinclair Sara and John Mpindi and Tuomas Mirtti and Paula Vainio and Juha K. Rantala and Kalle A. Alanen and Matthias Nees and Olli Kallioniemi},
  journal={Cancer research},
  year={2010},
  volume={70 17},
  pages={
          6735-45
        }
}
TMPRSS2-ERG and other gene fusions involving ETS factors and genes with strong promoter elements are common in prostate cancer. Although ERG activation has been linked to invasive properties of prostate cancers, the precise mechanisms and pathways of ERG-mediated oncogenesis remain poorly understood. Here, we show that ERG knockdown in VCaP prostate cancer cells causes an activation of cell adhesion, resulting in strongly induced active beta(1)-integrin and E-cadherin expression as well as… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 142 CITATIONS, ESTIMATED 74% COVERAGE

Roles of Wnt Target Genes in the Journey of Cancer Stem Cells

  • International journal of molecular sciences
  • 2017
VIEW 12 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2010
2019

CITATION STATISTICS

  • 5 Highly Influenced Citations

  • Averaged 10 Citations per year from 2017 through 2019

References

Publications referenced by this paper.
SHOWING 1-10 OF 28 REFERENCES

ETS ily transcription factors collaborate with alternative signaling thways to induce carcinoma from adult murine prostate cells

A Dobi, A Mohamed
  • Proc tl Acad Sci U S A
  • 2009

A causal role for ERG in neoplastic transformation of prostate epithelium.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2008

Role of the TMPRSS 2G gene fusion in prostate cancer

O zovitch, M Risk, I Coleman
  • Neoplasia
  • 2008

TMPRSS 2 - ERG fusion , a com - n genomic alteration in prostate cancer activates C - MYC and rogates prostate epithelial differentiation

M Wolf, H Edgren
  • Oncogene
  • 2008

Ac ac FZD4 as a Mediator of ERG-Induced WNT Signaling www.a D Published OnlineFirst

E rgineanu, CE Cotrutz, C. Cotrutz
  • Rev Med Chir Soc Med Nat Iasi
  • 2007
VIEW 1 EXCERPT

Comprehensive assessment of PRSS 2 and ETS family gene aberrations in clinically localized state cancer

S rner, JM Mosquera, F Demichelis
  • Mod Pathol
  • 2007

ImageJ for microscopy

S rner, F Demichelis, R Beroukhim
  • BioTechniques
  • 2007

Similar Papers

Loading similar papers…