FYVE domain targets Pib1p ubiquitin ligase to endosome and vacuolar membranes.

@article{Shin2001FYVEDT,
  title={FYVE domain targets Pib1p ubiquitin ligase to endosome and vacuolar membranes.},
  author={Marcus E. Shin and Kenyon D Ogburn and Oliver Adrian Varban and Penney M. Gilbert and Chris G Burd},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 44},
  pages={41388-93}
}
Signaling by phosphatidylinositol 3-kinases (PI3Ks) is often mediated by proteins which bind PI3K products directly and are localized to intracellular membranes rich in PI3K products. The FYVE finger domain binds with high specificity to PtdIns3P and proteins containing this domain have been shown to be important components of diverse PI3K signaling pathways. The genome of the yeast Saccharomyces cerevisiae encodes five proteins containing FYVE domains, including Pib1p, whose function is… CONTINUE READING

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