FXR1P is a GSK3β substrate regulating mood and emotion processing

@article{Delguidice2015FXR1PIA,
  title={FXR1P is a GSK3β substrate regulating mood and emotion processing},
  author={Thomas Del'guidice and C. Latapy and A. Rampino and J. Khlghatyan and M. Lemasson and B. Gelao and T. Quarto and G. Rizzo and A. Barbeau and C. Lamarre and A. Bertolino and G. Blasi and J. Beaulieu},
  journal={Proceedings of the National Academy of Sciences},
  year={2015},
  volume={112},
  pages={E4610 - E4619}
}
  • Thomas Del'guidice, C. Latapy, +10 authors J. Beaulieu
  • Published 2015
  • Psychology, Medicine
  • Proceedings of the National Academy of Sciences
  • Significance This study provides a cellular mechanism for the regulation of behavioral dimensions pertinent to mood disorders. Inhibition of glycogen synthase kinase 3β (GSK3β) is a shared action of drugs used for bipolar disorder. However, the substrates through which this kinase regulates mood are not known. We identified fragile X mental retardation-related protein 1 (FXR1P) as a substrate for GSK3β. Phosphorylation of FXR1P by GSK3β would lead to its down-regulation. Overexpression of FXR1P… CONTINUE READING
    39 Citations
    Fxr1 regulates sleep and synaptic homeostasis
    Are FXR Family Proteins Integrators of Dopamine Signaling and Glutamatergic Neurotransmission in Mental Illnesses?
    • 7
    • PDF
    Wnt and GSK3 Signaling Pathways in Bipolar Disorder: Clinical and Therapeutic Implications
    • Ather Muneer
    • Medicine
    • Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology
    • 2017
    • 31
    • PDF
    Motor Learning Deficits and Striatal GSK-3 Hyperactivity in Akt3 Knockout Mice
    The interaction of GSK3B and FXR1 genotypes may influence the mania and depression dimensions in mood disorders.
    • 13
    • Highly Influenced
    • PDF

    References

    SHOWING 1-10 OF 88 REFERENCES
    Mood stabilizers, glycogen synthase kinase-3β and cell survival
    • 116
    • PDF
    Mood stabilizers, glycogen synthase kinase-3beta and cell survival.
    • 63
    Role of GSK3β in behavioral abnormalities induced by serotonin deficiency
    • 319
    • PDF
    Selective deletion of forebrain glycogen synthase kinase 3β reveals a central role in serotonin-sensitive anxiety and social behaviour
    • 63
    • PDF
    Akt/GSK3 signaling in the action of psychotropic drugs.
    • 450
    • PDF
    Deletion of GSK3β in D2R-expressing neurons reveals distinct roles for β-arrestin signaling in antipsychotic and lithium action
    • 76
    • PDF
    In vivo regulation of glycogen synthase kinase-3beta (GSK3beta) by serotonergic activity in mouse brain.
    • 149
    Lithium antagonizes dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascade.
    • 714
    • Highly Influential
    • PDF