FXR1P is a GSK3β substrate regulating mood and emotion processing

  title={FXR1P is a GSK3β substrate regulating mood and emotion processing},
  author={Thomas Del'guidice and C. Latapy and A. Rampino and J. Khlghatyan and M. Lemasson and B. Gelao and T. Quarto and G. Rizzo and A. Barbeau and C. Lamarre and A. Bertolino and G. Blasi and J. Beaulieu},
  journal={Proceedings of the National Academy of Sciences},
  pages={E4610 - E4619}
  • Thomas Del'guidice, C. Latapy, +10 authors J. Beaulieu
  • Published 2015
  • Psychology, Medicine
  • Proceedings of the National Academy of Sciences
  • Significance This study provides a cellular mechanism for the regulation of behavioral dimensions pertinent to mood disorders. Inhibition of glycogen synthase kinase 3β (GSK3β) is a shared action of drugs used for bipolar disorder. However, the substrates through which this kinase regulates mood are not known. We identified fragile X mental retardation-related protein 1 (FXR1P) as a substrate for GSK3β. Phosphorylation of FXR1P by GSK3β would lead to its down-regulation. Overexpression of FXR1P… CONTINUE READING
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