FXR1P is a GSK3β substrate regulating mood and emotion processing.

@article{Delguidice2015FXR1PIA,
  title={FXR1P is a GSK3β substrate regulating mood and emotion processing.},
  author={Thomas Del'guidice and Camille Latapy and Antonio Rampino and Jivan Khlghatyan and Morgane Lemasson and Barbara Gelao and Tiziana Quarto and Giuseppe Rizzo and Annie Barbeau and Claude Lamarre and Alessandro Bertolino and Giuseppe Blasi and J M Beaulieu},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2015},
  volume={112 33},
  pages={
          E4610-9
        }
}
Inhibition of glycogen synthase kinase 3β (GSK3β) is a shared action believed to be involved in the regulation of behavior by psychoactive drugs such as antipsychotics and mood stabilizers. However, little is known about the identity of the substrates through which GSK3β affects behavior. We identified fragile X mental retardation-related protein 1 (FXR1P), a RNA binding protein associated to genetic risk for schizophrenia, as a substrate for GSK3β. Phosphorylation of FXR1P by GSK3β is… CONTINUE READING
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