• Medicine
  • Published in Journal of lipid research 2006

FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine.

@article{Lee2006FXRRO,
  title={FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine.},
  author={Hans E. Lee and Yanqiao Zhang and Florence Ying Lee and Stanley F. Nelson and Frank J. Gonzalez and Peter A. Edwards},
  journal={Journal of lipid research},
  year={2006},
  volume={47 1},
  pages={
          201-14
        }
}
Expression of the farnesoid X receptor (FXR; NR1H4) is limited to the liver, intestine, kidney, and adrenal gland. However, the role of FXR in the latter two organs is unknown. In the current study, we performed microarray analysis using RNA from H295R cells infected with constitutively active FXR. Several putative FXR target genes were identified, including the organic solute transporters alpha and beta (OSTalpha and OSTbeta). Electromobility shift assays and promoter-reporter studies… CONTINUE READING

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Regulation of complement C3 expression by the bile acid receptor FXR.

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