FXR regulates liver repair after CCl4-induced toxic injury.

  title={FXR regulates liver repair after CCl4-induced toxic injury.},
  author={Zhipeng Meng and Yandong Wang and Lin Jun Wang and Wen Jin and N Liu and Hao Pan and Lucy Liu and Lawrence David Wagman and Barry Marc Forman and Wendong Huang},
  journal={Molecular endocrinology},
  volume={24 5},
Liver repair is key to resuming homeostasis and preventing fibrogenesis as well as other liver diseases. Farnesoid X receptor (FXR, NR1H4) is an emerging liver metabolic regulator and cell protector. Here we show that FXR is essential to promote liver repair after carbon tetrachloride (CCl(4))-induced injury. Expression of hepatic FXR in wild-type mice was strongly suppressed by CCl(4) treatment, and bile acid homeostasis was disrupted. Liver injury was induced in both wild-type and FXR… CONTINUE READING
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