FXR antagonism of NSAIDs contributes to drug-induced liver injury identified by systems pharmacology approach

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) are worldwide used drugs for analgesic, antipyretic, and anti-inflammatory therapeutics. However, NSAIDs often cause several serious liver injuries, such as drug-induced liver injury (DILI), and the molecular mechanisms of DILI have not been clearly elucidated. In this study, we developed a systems pharmacology… (More)
DOI: 10.1038/srep08114

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Cite this paper

@inproceedings{Lu2015FXRAO, title={FXR antagonism of NSAIDs contributes to drug-induced liver injury identified by systems pharmacology approach}, author={Weiqiang Lu and Feixiong Cheng and Jing Jiang and Chen Zhang and Xiaokang Deng and Zhongyu Xu and Shi-en Zou and Xu Shen and Yun Tang and Jin Huang}, booktitle={Scientific reports}, year={2015} }