FXR and PXR: Potential therapeutic targets in cholestasis

@article{Jonker2012FXRAP,
  title={FXR and PXR: Potential therapeutic targets in cholestasis},
  author={Johan W. Jonker and Christopher Liddle and Michael Frank Downes},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={2012},
  volume={130},
  pages={147-158}
}
Cholestatic liver disorders encompass hepatobiliary diseases of diverse etiologies characterized by the accumulation of bile acids, bilirubin and cholesterol as the result of impaired secretion of bile. Members of the nuclear receptor (NR) family of ligand-modulated transcription factors are implicated in the adaptive response to cholestasis. NRs coordinately regulate bile acid and phospholipid transporter genes required for hepatobiliary transport, as well as the phases I and II metabolizing… CONTINUE READING
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