FXR activation normalizes insulin sensitivity in visceral preadipocytes of a rabbit model of MetS.

@article{Maneschi2013FXRAN,
  title={FXR activation normalizes insulin sensitivity in visceral preadipocytes of a rabbit model of MetS.},
  author={E. Maneschi and L. Vignozzi and A. Morelli and T. Mello and S. Filippi and I. Cellai and P. Comeglio and E. Sarchielli and A. Calcagno and B. Mazzanti and R. Vettor and G. Vannelli and L. Adorini and M. Maggi},
  journal={The Journal of endocrinology},
  year={2013},
  volume={218 2},
  pages={
          215-31
        }
}
Insulin resistance is the putative key underlying mechanism linking adipose tissue (AT) dysfunction with liver inflammation and steatosis in metabolic syndrome (MetS). We have recently demonstrated that the selective farnesoid X receptor (FXR) agonist obeticholic acid (OCA) ameliorates insulin resistance and the metabolic profile with a marked reduction in the amount of visceral AT (VAT) in a high-fat diet (HFD)-induced rabbit model of MetS. These effects were mediated by the activation of FXR… Expand
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