FUS and TARDBP but Not SOD1 Interact in Genetic Models of Amyotrophic Lateral Sclerosis

@inproceedings{Kabashi2011FUSAT,
  title={FUS and TARDBP but Not SOD1 Interact in Genetic Models of Amyotrophic Lateral Sclerosis},
  author={Edor Kabashi and Val{\'e}rie Bercier and Alexandra Lissouba and Meijiang Liao and Edna Brustein and Guy Rouleau and Pierre Drapeau},
  booktitle={PLoS genetics},
  year={2011}
}
Mutations in the SOD1 and TARDBP genes have been commonly identified in Amyotrophic Lateral Sclerosis (ALS). Recently, mutations in the Fused in sarcoma gene (FUS) were identified in familial (FALS) ALS cases and sporadic (SALS) patients. Similarly to TDP-43 (coded by TARDBP gene), FUS is an RNA binding protein. Using the zebrafish (Danio rerio), we examined the consequences of expressing human wild-type (WT) FUS and three ALS-related mutations, as well as their interactions with TARDBP and… CONTINUE READING
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