FUS-CREB3L2/L1-positive sarcomas show a specific gene expression profile with upregulation of CD24 and FOXL1.

  title={FUS-CREB3L2/L1-positive sarcomas show a specific gene expression profile with upregulation of CD24 and FOXL1.},
  author={Emely M{\"o}ller and Jason L Hornick and Linda Magnusson and Srinivas Veerla and Henryk A. Domanski and Fredrik Mertens},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={17 9},
PURPOSE Low-grade fibromyxoid sarcoma (LGFMS) is typically characterized by the specific translocation t(7;16)(q33;p11) and the corresponding fusion gene FUS-CREB3L2. The present study aimed to extract LGFMS-specific, and putatively FUS-CREB3L2-dependent, gene expression patterns to learn more about the pathogenesis of this tumor. EXPERIMENTAL DESIGN We carried out single nucleotide polymorphism (SNP) and global gene expression array analyses, and/or immunohistochemical (IHC) analyses on 24… CONTINUE READING
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