FURTHER EVIDENCE FAVORING THE CONCEPT OF THE STEM CELL IN ASCITES TUMORS OF RATS

@article{Makino1956FURTHEREF,
  title={FURTHER EVIDENCE FAVORING THE CONCEPT OF THE STEM CELL IN ASCITES TUMORS OF RATS},
  author={Sajiro Makino},
  journal={Annals of the New York Academy of Sciences},
  year={1956},
  volume={63}
}
  • S. Makino
  • Published 1 July 1955
  • Biology
  • Annals of the New York Academy of Sciences
Cytological investigations based on morphological and statisticzl analysis of the chromosomes in several ascites tumors of rats conducted by the present author in collaboratioii with his co-workers have revealed tlie existence of the stem line (or stem lines) of tumor cells as primary contributors to the growth of the tumor. T t has been shown that in each of the tumors studied, populations of tumor cells persist characterized by a high frequency of definite chromosome patterns specific to the… 

Further data on the common origin of various stem-lines in human tumors.

A human tumor with several stem-lines the relationship of which could be esta blished by chromosome study is presented.

[GANN, 49, 331-340; December, 1958] CYTOLOGICAL STUDIES OF TUMORS, XXIV. AN AZO-DYE INDUCED ASCITES HEPATOMA OF THE RAT, WITH SPECIAL REMARKS ON TRANSITIONAL CHANGES OF NEOPLASTIC CHARACTERS IN THE COURSE OF SERIAL TRANSFERS (Plates XXVII and XXVIII)

The present paper gives some information about the shifts in the chromosome pattern of such an ascites hepatoma induced by azo-dye application in a rat and some other transitional changes occurring in neoplastic characters during serial transfers.

Cytological Studies of Tumors, XXIII

A comparison of the chromosomes between the Yoshida sarcoma subline A and its single-cell clone was found to be similar in their chromosome pattern.

Mitotic cell studies based on in vivo observations. VII. The intrinsic nature of cancer cells and of carcinogenesis as interpreted from the viewpoint in reference to cell biology.

The cause of carcinogenesis still remains as one of most difficult unsolved pro blems, but all cancer investigators recognize the fact that cancer cells unrestrictedly can increase by cell division

Differentiation of malignant to benign cells.

It would appear that the progeny of malignant stem cells can differentiate into postmitotic benign cells incapable of forming a tumor.

Cancer Stem Cells: On the Verge of Clinical Translation

Demonstration of the ability to self-renew, a key feature of stem cells, is achieved through serial passage of tumors in xenohosts, and the impact of cancer stem cells on the practice of medicine is likely to be profound.

Ultrastructure of human testicular tumors

A basis is established for the occurrence of multiple types of testicular tumor in one testis and for the histogenesis of the various germinal tumors of the testicle.

MULTIPOTENTIALITY OF SINGLE EMBRYONAL CARCINOMA CELLS.

The capacity of single embryonal carcinoma cells to differentiate into benign tissues supports neither the dogma of the irreversibility of the malignant transformation nor the somatic cell mutation theory of cancer.
...

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  • T. Hauschka
  • Medicine
    Transactions of the New York Academy of Sciences
  • 1953