FULL PAPER Cyclisation of Novel Amino Oxo Esters to Tetramic Acids Density Functional Theory Study of the Reaction Mechanism


The pyrrolidine-2,4-dione ring system (tetramic acid) is present in various naturally occurring compounds exhibiting a wide range of biological and pharmaceutical activities.[1] Representative examples are erythroskyrine[2] [a mycotoxin containing an N-methyl-(S)-valine-derived acyltetramic acid terminus] and fuligorubin A[3] [a pigment from the slime mould… (More)


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