FTY720 inhibits proliferation and epithelial-mesenchymal transition in cholangiocarcinoma by inactivating STAT3 signaling

@inproceedings{Lu2014FTY720IP,
  title={FTY720 inhibits proliferation and epithelial-mesenchymal transition in cholangiocarcinoma by inactivating STAT3 signaling},
  author={Zhaoyang Lu and Jiabei Wang and Tongsen Zheng and Yingjian Liang and Dalong Yin and Ruipeng Song and Tiemin Pei and Shangha Pan and HongChi Jiang and Lianxin Liu},
  booktitle={BMC Cancer},
  year={2014}
}
Interleukin 6 (IL-6)-mediated signal transducers and activators of transcription 3 (STAT-3) phosphorylation (activation) is aberrantly sustained in cholangiocarcinoma cells resulting in enhanced myeloid cell leukemia 1 (Mcl-1) expression and resistance to apoptosis. FTY720, a new immunosuppressant, derived from ISP-1, has been studied for its putative anti-cancer properties. This study aimed to elucidate the mechanism by which FTY720 mediates antitumor effects in cholangiocarcinoma (CC) cells… CONTINUE READING
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