FTY720 exerts a survival advantage through the prevention of end-stage glomerular inflammation in lupus-prone BXSB mice.

@article{Ando2010FTY720EA,
  title={FTY720 exerts a survival advantage through the prevention of end-stage glomerular inflammation in lupus-prone BXSB mice.},
  author={Seiichiro Ando and Hirofumi Amano and Eri Amano and Kentaro Minowa and Takashi Watanabe and Soichiro Nakano and Yutaka Nakiri and Shinji Morimoto and Yoshiaki Tokano and Qingshun Lin and Rong Hou and Mareki Ohtsuji and Hiromichi Tsurui and S. Hirose and Yoshinari Takasaki},
  journal={Biochemical and biophysical research communications},
  year={2010},
  volume={394 3},
  pages={804-10}
}
FTY720 is a novel investigational agent targeting the sphingosine 1-phosphate (S1P) receptors with an ability to cause immunosuppression by inducing lymphocyte sequestration in lymphoid organs. Systemic lupus erythematosus (SLE) is refractory autoimmune disease characterized by the production of a wide variety of autoantibodies and immune complex (IC)-mediated lupus nephritis. Among several SLE-prone strains of mice, BXSB is unique in terms of the disease-associated monocytosis in periphery and… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-8 of 8 extracted citations

Sphingolipid signaling in renal fibrosis.

Matrix biology : journal of the International Society for Matrix Biology • 2018
View 1 Excerpt

Similar Papers

Loading similar papers…