FTY720 ameliorates GvHD by blocking T lymphocyte migration to target organs and by skin fibrosis inhibition

@article{Ryu2020FTY720AG,
  title={FTY720 ameliorates GvHD by blocking T lymphocyte migration to target organs and by skin fibrosis inhibition},
  author={Jaeyoon Ryu and Jooyeon Jhun and M. Park and J. Baek and Seyoung Kim and Keun-Hyung Cho and Jeong-Won Choi and Sung-Hwan Park and Jong Sub Choi and M. Cho},
  journal={Journal of Translational Medicine},
  year={2020},
  volume={18}
}
  • Jaeyoon Ryu, Jooyeon Jhun, +7 authors M. Cho
  • Published 2020
  • Medicine
  • Journal of Translational Medicine
  • Background Fibrosis is the formation of excess connective tissue in an organ or tissue during a reparative or reactive process. Graft-versus-host disease (GvHD) is a medical complication of allogeneic tissue transplantation with transplanted donor T cell-mediated inflammatory response; it is characterized by a severe immune response with fibrosis in the final stage of the inflammatory process. T helper 17 cells play a critical role in the pathogenesis of GvHD. Fingolimod (FTY720), an analogue… CONTINUE READING

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 39 REFERENCES
    Allogeneic haematopoietic stem cell transplantation: current status and future outlook.
    37
    CC chemokine receptor 7‐dependent and Page 13 of 13 Ryu et al
    • 2001
    Cutting Edge: Suppression of T Cell Chemotaxis by Sphingosine 1-Phosphate1
    131
    Emerging multiple sclerosis oral therapies. Neurology. 2010;74(Suppl 1):S47–53
    • 2010