FTY720 Reduces Post-Ischemic Brain Lymphocyte Influx but Does Not Improve Outcome in Permanent Murine Cerebral Ischemia

@inproceedings{Liesz2011FTY720RP,
  title={FTY720 Reduces Post-Ischemic Brain Lymphocyte Influx but Does Not Improve Outcome in Permanent Murine Cerebral Ischemia},
  author={Arthur Liesz and Li Sun and Wei Zhou and S{\"o}nke Schwarting and Eva Mracsk{\'o} and Markus Zorn and Henrike Bauer and Clemens J Sommer and Roland Veltkamp},
  booktitle={PloS one},
  year={2011}
}
BACKGROUND The contribution of neuroinflammation and specifically brain lymphocyte invasion is increasingly recognised as a substantial pathophysiological mechanism after stroke. FTY720 is a potent treatment for primary neuroinflammatory diseases by inhibiting lymphocyte circulation and brain immigration. Previous studies using transient focal ischemia models showed a protective effect of FTY720 but did only partially characterize the involved pathways. We tested the neuroprotective properties… CONTINUE READING