FTY720 (fingolimod) for relapsing multiple sclerosis

@article{Horga2008FTY720F,
  title={FTY720 (fingolimod) for relapsing multiple sclerosis},
  author={Alejandro Horga and Xavier Montalban},
  journal={Expert Review of Neurotherapeutics},
  year={2008},
  volume={8},
  pages={699 - 714}
}
FTY720 (fingolimod) is a structural analogue of sphingosine, an endogenous lysophospholipid, which targets sphingosine-1-phosphate receptors after biotransformation to FTY720-phosphate. The immunomodulatory properties of this agent are mainly related to its ability to entrap lymphocytes in secondary lymphoid organs, reducing their availability for cell-mediated immune responses. Emerging evidence suggests that FTY720 also exerts direct actions on glial and precursor cells of the CNS which may… 

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