FTY720 (Fingolimod) Attenuates Beta-amyloid Peptide (Aβ42)-Induced Impairment of Spatial Learning and Memory in Rats

@article{AsleRousta2013FTY720A,
  title={FTY720 (Fingolimod) Attenuates Beta-amyloid Peptide (Aβ42)-Induced Impairment of Spatial Learning and Memory in Rats},
  author={Masoumeh Asle-Rousta and Zeynab Kolahdooz and Shahrbanoo Oryan and Abolhassan Ahmadiani and Leila Dargahi},
  journal={Journal of Molecular Neuroscience},
  year={2013},
  volume={50},
  pages={524-532}
}
Imbalanced lipid metabolism and increase in the ceramide-to-S1P ratio in the brain have been postulated to play a role in amyloidogenesis, neuroinflammatory reactions, and neuronal apoptosis in Alzheimer’s disease (AD) pathology. FTY720, the immunomodulatory sphingosine 1-phosphate (S1P) analog, has recently gained interest because of its CNS-directed effects. In addition to its immunomodulatory functions in multiple sclerosis, FTY720 possesses anti-inflammatory and neuroprotective roles in… CONTINUE READING
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The rat brain in stereotaxic coordinates

  • G Paxinos, C Watson
  • 6th edn. Academic,
  • 2007
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