FTY720, a synthetic compound from Isaria sinclairii, inhibits proliferation and induces apoptosis in pancreatic cancer cells.

@article{Shen2007FTY720AS,
  title={FTY720, a synthetic compound from Isaria sinclairii, inhibits proliferation and induces apoptosis in pancreatic cancer cells.},
  author={Yan Shen and Minxia Cai and Weiliang Xia and Junwei Liu and Qiyi G. Zhang and Hai-Yang Xie and Chen Wang and Xiaohui Wang and Shusen Zheng},
  journal={Cancer letters},
  year={2007},
  volume={254 2},
  pages={
          288-97
        }
}
FTY720, a synthetic compound produced by modification of a metabolite from Isaria sinclairii, is known as a unique immunosuppressive agent that exerts its activity by inducing apoptosis of lymphocytes [S. Suzuki, FTY720: Mechanisms of action and its effect on organ transplantation, Transplant. Proc. 31 (1999) 2779-2782]. Additionally, it has been found that FTY720 has inhibitory effects on various cancer growth and metastasis [J.D. Wang, S. Takahara, N. Nonomura, Early induction of apoptosis in… CONTINUE READING
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