FTO rs 9939609 SNP Is Associated With Adiponectin and Leptin Levels and the Risk of Obesity in a Cohort of Romanian Children Population

@article{Duicu2016FTOR9,
  title={FTO rs 9939609 SNP Is Associated With Adiponectin and Leptin Levels and the Risk of Obesity in a Cohort of Romanian Children Population},
  author={Carmen Duicu and Cristina Oana Mărginean and Septimiu Voidăzan and Florin Tripon and Claudia Bănescu},
  journal={Medicine},
  year={2016},
  volume={95}
}
Abstract Obesity is a disorder with increasing frequency in children and adolescents, directly linked with various diseases. Variants in the FTO (fat mass and obesity-related) gene have been associated with body mass index and waist and hip circumferences in widespread populations. The aim of this case-control study was to assess if there is any association between FTO gene variants rs9939609, respectively, rs17817449 with anthropometric and metabolic biomarkers (fasting glucose, TC, HDL… 
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28 Citations
Background Citations
9
Methods Citations
1
Results Citations
2

28 Citations

Association of FTO rs9939609 polymorphism with serum leptin, insulin, adiponectin, and lipid profile in overweight adults
TLDR
In conclusion, rs9939609 risk allele was associated with higher serum leptin and lower HDL levels in overweight people, and the association remained significant for HDL level after adjustments for age and sex, calorie intake, physical activity, and BMI.
Correlation between adiponectin level with common variant (rs9939609) of fat mass and obesity-associated gene in obese type 2 diabetic women
TLDR
The association of rs9939609 FTO polymorphism was significant with FBS, HbA1c, TG, insulin, HOMA and adiponectin level in obese diabetic women who harbored the mutant A allele.
Obesity Risk Prediction among Women of Upper Egypt: The impact of FTO rs17817449 gene polymorphism, serum ghrelin and high sensitivity C- reactive protein
TLDR
The G allele of FTO rs17817449 genotyping is associated with increased obesity risk but there is a lack of association with diabetes.
Correlation of Resistin Serum Level with Fat Mass and Obesity-Associated Gene (FTO) rs9939609 Polymorphism in Obese Women with Type 2 Diabetes.
Evaluation of FTO rs9939609 and MC4R rs17782313 Polymorphisms as Prognostic Biomarkers of Obesity: A Population-based Cross-sectional Study
TLDR
This study shows a relationship between FTO polymorphism and increased BMI, therefore, SNP in the FTO gene influence changes in BMI and can be considered a prognostic marker of obesity risk.
Differential distribution and association of FTO rs9939609 gene polymorphism with obesity: A cross-sectional study among two tribal populations of India with East-Asian ancestry.
Association between Polymorphisms of FTO Gene and Obesity
TLDR
Evaluation of association between polymorphisms in FTO gene and obesity concludes that genetically predisposed individuals who are susceptible to obesity need to special attention for combating obesity-related problems and promotion of their health.
Association Metabolic Obesity Phenotypes with Cardiometabolic Index, Atherogenic Index of Plasma and Novel Anthropometric Indices: A Link of FTO-rs9939609 Polymorphism
TLDR
Normal-weight individuals with metabolic unhealthy status are at higher risk for cardiovascular diseases than obese individuals with metabolically healthy status.
Implications of visfatin genetic variants in the metabolic profile of the Romanian pediatric population
TLDR
NAMPT rs2302559 and rs4730153 polymorphisms do not seem to have a major impact in the development of obesity in children, however there may be an association with lipid profile, but further studies are needed.
FTO genotype and weight status among preadolescents: Assessing the mediating effects of obesogenic appetitive traits
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References

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TLDR
The FTO gene polymorphism may partially explain the predisposition to obesity in the population of Polish children and the potential effect on the remaining cardiovascular risk factors seems indirect and dependent on BMI changes.
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TLDR
The minor A allele of the FTO rs9939609 was significantly associated with higher serum leptin concentrations independently of potential confounders including adiposity, which could linkThe FTO gene with serum leptin and consequently with the control of energy balance.
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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