FTO regulates the chemo-radiotherapy resistance of cervical squamous cell carcinoma (CSCC) by targeting β-catenin through mRNA demethylation.

@article{Zhou2018FTORT,
  title={FTO regulates the chemo-radiotherapy resistance of cervical squamous cell carcinoma (CSCC) by targeting β-catenin through mRNA demethylation.},
  author={Shun Zhou and Zhou-lan Bai and Di Xia and Zhi-Jun Zhao and Ren Zhao and Yan-Yang Wang and Hong Zhe},
  journal={Molecular carcinogenesis},
  year={2018},
  volume={57 5},
  pages={590-597}
}
The role of N6 -methyladenosine (m6 A) demethylase fat mass and obesity-associated protein (FTO) in the regulation of chemo-radiotherapy resistance remains largely unknown. Here, we show that the mRNA level of FTO is elevated in cervical squamous cell carcinoma (CSCC) tissues when compared with respective adjacent normal tissues. FTO enhances the chemo-radiotherapy resistance both in vitro and in vivo through regulating expression of β-catenin by reducing m6 A levels in its mRNA transcripts and… CONTINUE READING
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