FTO modulates circadian rhythms and inhibits the CLOCK-BMAL1-induced transcription.

  title={FTO modulates circadian rhythms and inhibits the CLOCK-BMAL1-induced transcription.},
  author={Chao-Yung Wang Wang and Shian-Sen Shie and I-Chang Hsieh and Ming-Lung Tsai and Ming-Shien Wen},
  journal={Biochemical and biophysical research communications},
  volume={464 3},
Variations in the human fat mass and obesity-associated gene, which encodes FTO, an 2-oxoglutarate-dependent nucleic acid demethylase, are associated with increased risk of obesity. These FTO variations were recently shown to affect IRX3 and the exact function of FTO is still controversial. Obesity is closely linked to circadian rhythm. To understand the role of FTO in circadian rhythm, we analyzed the circadian rhythm of FTO deficient mice. FTO deficient mice had robust circadian locomotor… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 5 times over the past 90 days. VIEW TWEETS


Publications referenced by this paper.
Showing 1-10 of 25 references

Hypomorphism for RPGRIP1L

  • G. Stratigopoulos, J. F. Martin Carli, +8 authors R. L. Leibel
  • a ciliary gene vicinal to the FTO locus, causes…
  • 2014
1 Excerpt

Similar Papers

Loading similar papers…