FTO modulates circadian rhythms and inhibits the CLOCK-BMAL1-induced transcription.

@article{Wang2015FTOMC,
  title={FTO modulates circadian rhythms and inhibits the CLOCK-BMAL1-induced transcription.},
  author={Chao-Yung Wang Wang and Shian-Sen Shie and I-Chang Hsieh and Ming-Lung Tsai and Ming-Shien Wen},
  journal={Biochemical and biophysical research communications},
  year={2015},
  volume={464 3},
  pages={826-32}
}
Variations in the human fat mass and obesity-associated gene, which encodes FTO, an 2-oxoglutarate-dependent nucleic acid demethylase, are associated with increased risk of obesity. These FTO variations were recently shown to affect IRX3 and the exact function of FTO is still controversial. Obesity is closely linked to circadian rhythm. To understand the role of FTO in circadian rhythm, we analyzed the circadian rhythm of FTO deficient mice. FTO deficient mice had robust circadian locomotor… CONTINUE READING
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