FTD and ALS: Genetic Ties that Bind

@article{Orr2011FTDAA,
  title={FTD and ALS: Genetic Ties that Bind},
  author={Harry T. Orr},
  journal={Neuron},
  year={2011},
  volume={72},
  pages={189-190}
}
Curiously, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), seemingly disparate neurodegenerative disorders, can be inherited together. Two groups (DeJesus-Hernandez et al. and Renton et al.) show that the long sought after ALS/FTD mutation on chromosomal region 9p is a hexanucleotide expansion in C90RF72. These studies, plus a study on X-linked ALS/FTD, provide molecular starting points for identifying pathways that link ALS and FTD pathogenesis. 

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The ITALSGEN Consortium

  • Nat. Neurosci
  • 2011

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