FSTL3 deletion reveals roles for TGF-beta family ligands in glucose and fat homeostasis in adults.

@article{Mukherjee2007FSTL3DR,
  title={FSTL3 deletion reveals roles for TGF-beta family ligands in glucose and fat homeostasis in adults.},
  author={Abir Mukherjee and Yisrael Sidis and Amy L Mahan and Michael J. Raher and Yin Ben Xia and Evan D Rosen and Kenneth D. Bloch and Melissa K. Thomas and Alan L. Schneyer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 4},
  pages={1348-53}
}
Activin and myostatin are related members of the TGF-beta growth factor superfamily. FSTL3 (Follistatin-like 3) is an activin and myostatin antagonist whose physiological role in adults remains to be determined. We found that homozygous FSTL3 knockout adults developed a distinct group of metabolic phenotypes, including increased pancreatic islet number and size, beta cell hyperplasia, decreased visceral fat mass, improved glucose tolerance, and enhanced insulin sensitivity, changes that might… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 46 extracted citations

Activin in glucose metabolism.

Vitamins and hormones • 2011
View 3 Excerpts
Highly Influenced

Activins and Inhibins: Roles in Development, Physiology, and Disease.

Cold Spring Harbor perspectives in biology • 2016
View 2 Excerpts

Similar Papers

Loading similar papers…