FSTL1 promotes arthritis in mice by enhancing inflammatory cytokine/chemokine expression.

@article{Chaly2012FSTL1PA,
  title={FSTL1 promotes arthritis in mice by enhancing inflammatory cytokine/chemokine expression.},
  author={Yury Chaly and Anthony D. Marinov and Leif Oxburgh and Daniel S. Bushnell and Raphael Hirsch},
  journal={Arthritis and rheumatism},
  year={2012},
  volume={64 4},
  pages={
          1082-8
        }
}
OBJECTIVE FSTL1 is a secreted glycoprotein that exacerbates murine arthritis and is overexpressed in human arthritis. The aim of this study was to determine the mechanism by which FSTL1 promotes arthritis. METHODS Collagen-induced arthritis was induced in mice hypomorphic for FSTL1, generated with a gene trap-targeted mutant embryonic stem cell line. Arthritis was assessed by measuring paw swelling and using a qualitative arthritis index. Bone marrow-derived mesenchymal stromal cells from… CONTINUE READING
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