FSP27 and PLIN1 interaction promotes the formation of large lipid droplets in human adipocytes.

@article{Grahn2013FSP27AP,
  title={FSP27 and PLIN1 interaction promotes the formation of large lipid droplets in human adipocytes.},
  author={Tan Hooi Min Grahn and Yan Zhang and M D Lee and Andreia Gianotti Sommer and Gustavo Mostoslavsky and Susan K. Fried and Andrew S Greenberg and Vishwajeet Puri},
  journal={Biochemical and biophysical research communications},
  year={2013},
  volume={432 2},
  pages={296-301}
}
Human adipocytes express high levels of two distinct lipid droplet proteins, fat specific protein 27 (FSP27; also called CIDEC), a member of the CIDE family, and perilipin1 (PLIN1), a member of the PAT family. Both proteins play a role in fat metabolism in adipocytes, but how they interact is not known. Our present study demonstrates that FSP27 and PLIN1 co-localize and interact in cultured human primary adipocytes. We also found that the C-terminal domain of FSP27, aa 120-220, interacts with… CONTINUE READING

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