FSHIP2 regulates epithelial cell polarity through its lipid product, which binds to Dlg1, a pathway subverted by hepatitis C virus core protein

@inproceedings{Awad2013FSHIP2RE,
  title={FSHIP2 regulates epithelial cell polarity through its lipid product, which binds to Dlg1, a pathway subverted by hepatitis C virus core protein},
  author={Aline Awad and Sokhavuth Sar and Ronan Barr{\'e} and Clotilde Cariven and Mickael Marin and Jean Pierre Salles and Christophe Erneux and Didier Samuel and Ama Gassama-Diagne},
  booktitle={Molecular biology of the cell},
  year={2013}
}
The main targets of hepatitis C virus (HCV) are hepatocytes, the highly polarized cells of the liver, and all the steps of its life cycle are tightly dependent on host lipid metabolism. The interplay between polarity and lipid metabolism in HCV infection has been poorly investigated. Signaling lipids, such as phosphoinositides (PIs), play a vital role in polarity, which depends on the distribution and expression of PI kinases and PI phosphatases. In this study, we report that HCV core protein… CONTINUE READING
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