FSHD muscular dystrophy region gene 1 binds Suv4-20h1 histone methyltransferase and impairs myogenesis.

@article{Neguembor2013FSHDMD,
  title={FSHD muscular dystrophy region gene 1 binds Suv4-20h1 histone methyltransferase and impairs myogenesis.},
  author={M. V. Neguembor and Alexandros Xynos and M. C. Onorati and R. Caccia and S. Bortolanza and C. Godio and M. Pistoni and D. Corona and G. Schotta and D. Gabellini},
  journal={Journal of molecular cell biology},
  year={2013},
  volume={5 5},
  pages={
          294-307
        }
}
Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal dominant myopathy with a strong epigenetic component. It is associated with deletion of a macrosatellite repeat leading to over-expression of the nearby genes. Among them, we focused on FSHD region gene 1 (FRG1) since its over-expression in mice, Xenopus laevis and Caenorhabditis elegans, leads to muscular dystrophy-like defects, suggesting that FRG1 plays a relevant role in muscle biology. Here we show that, when over-expressed… Expand
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