FSHD muscular dystrophy region gene 1 binds Suv4-20h1 histone methyltransferase and impairs myogenesis.

@article{Neguembor2013FSHDMD,
  title={FSHD muscular dystrophy region gene 1 binds Suv4-20h1 histone methyltransferase and impairs myogenesis.},
  author={Maria Victoria Neguembor and Alexandros Xynos and Maria Cristina Onorati and Roberta Caccia and Sergia Bortolanza and Cristina Godio and Mariaelena Pistoni and Davide F. V. Corona and Gunnar Schotta and Davide Gabellini},
  journal={Journal of molecular cell biology},
  year={2013},
  volume={5 5},
  pages={
          294-307
        }
}
Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal dominant myopathy with a strong epigenetic component. It is associated with deletion of a macrosatellite repeat leading to over-expression of the nearby genes. Among them, we focused on FSHD region gene 1 (FRG1) since its over-expression in mice, Xenopus laevis and Caenorhabditis elegans, leads to muscular dystrophy-like defects, suggesting that FRG1 plays a relevant role in muscle biology. Here we show that, when over-expressed… CONTINUE READING

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