FSHD Myotubes with Different Phenotypes Exhibit Distinct Proteomes

  title={FSHD Myotubes with Different Phenotypes Exhibit Distinct Proteomes},
  author={Alexandra Tassin and Baptiste Leroy and Dalila Laoudj-Chenivesse and Armelle Wauters and C{\'e}line Vanderplanck and Marie-Catherine Le Bihan and Fr{\'e}d{\'e}rique Copp{\'e}e and Ruddy Wattiez and Alexandra Belayew},
  booktitle={PloS one},
Facioscapulohumeral muscular dystrophy (FSHD) is a progressive muscle disorder linked to a contraction of the D4Z4 repeat array in the 4q35 subtelomeric region. This deletion induces epigenetic modifications that affect the expression of several genes located in the vicinity. In each D4Z4 element, we identified the double homeobox 4 (DUX4) gene. DUX4 expresses a transcription factor that plays a major role in the development of FSHD through the initiation of a large gene dysregulation cascade… CONTINUE READING
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