FSH versus estrogen: who's guilty of breaking bones?

@article{Baron2006FSHVE,
  title={FSH versus estrogen: who's guilty of breaking bones?},
  author={Roland Baron},
  journal={Cell metabolism},
  year={2006},
  volume={3 5},
  pages={302-5}
}
Bone loss after menopause or gonadectomy has been attributed to the drop in estrogen levels. A recent paper (Sun et al, 2006) challenges this view by showing that the pituitary hormone FSH, previously thought to target only the gonads, also acts on osteoclasts to activate bone resorption. In conjunction with genetic studies, these data raise the possibility that FSH, independent of estrogen, causes hypogonadal bone loss. 

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High bone density and bone health.

Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion • 2012

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Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology • 2012

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Proceedings of the National Academy of Sciences of the United States of America • 2010

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