FSH-induced resumption of meiosis in mouse oocytes: effect of different isoforms.

@article{Andersen1999FSHinducedRO,
  title={FSH-induced resumption of meiosis in mouse oocytes: effect of different isoforms.},
  author={Claus Yding Andersen and Lise Leonardsen and Alfredo Ulloa-Aguirre and Jorgelina Barrios-de-Tomasi and Ls Moore and Anne Grete Sjolte Byskov},
  journal={Molecular human reproduction},
  year={1999},
  volume={5 8},
  pages={
          726-31
        }
}
The ability of different isoforms of follicle stimulating hormone (FSH) to induce the resumption of meiosis in cultured mouse oocytes was evaluated. Oocytes were cultured in the presence of hypoxanthine to prevent spontaneous resumption of meiosis. Using serial dilutions of the isoform fractions representing less acidic isoforms (pI 6. 43-5.69), mid-acidic (pI 5.62-4.96) and acidic (pI 4.69-3.75), the concentration which caused 50% of the oocytes to resume meiosis and undergo germinal vesicle… CONTINUE READING

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