FSH-induced expansion of the mouse cumulus oophorus in vitro is dependent upon a specific factor(s) secreted by the oocyte.

@article{Buccione1990FSHinducedEO,
  title={FSH-induced expansion of the mouse cumulus oophorus in vitro is dependent upon a specific factor(s) secreted by the oocyte.},
  author={R Buccione and Barbara C Vanderhyden and Philippe J. Caron and John J. Eppig},
  journal={Developmental biology},
  year={1990},
  volume={138 1},
  pages={16-25}
}
Although it has been shown that granulosa cells regulate the growth and meiotic maturation of mammalian oocytes, there is little evidence of a role for the oocyte in the differentiation or function of granulosa cells. To test the hypothesis that the oocyte participates in the regulation of granulosa cell function, oocytes were removed from isolated oocyte-cumulus cell complexes by a microsurgical procedure and oocytectomized complexes were tested for their ability to undergo expansion in… CONTINUE READING

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