FSH Stimulation promotes progesterone synthesis and output from human granulosa cells without luteinization

@article{Oktem2017FSHSP,
  title={FSH Stimulation promotes progesterone synthesis and output from human granulosa cells without luteinization},
  author={Ozgur Oktem and Nazli Akin and Gamze Bildik and Kayhan Yakın and Ebru Alper and Başak Balaban and Bulent Urman},
  journal={Human Reproduction},
  year={2017},
  volume={32},
  pages={643–652}
}
STUDY QUESTION Can granulosa cells produce progesterone (P) in response to FSH stimulation? SUMMARY ANSWER FSH actively promotes P synthesis and output from granulosa cells without luteinization by up-regulating the expression and increasing enzymatic activity of 3β-hydroxysteriod dehydrogenoase (3β-HSD), which converts pregnenolone to P. WHAT IS KNOWN ALREADY Serum P level may rise prematurely prior to ovulation trigger in stimulated IVF cycles and adversely affect implantation and… 

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