FRONTIER Executive Screen: a brief executive battery to differentiate frontotemporal dementia and Alzheimer's disease

@article{Leslie2015FRONTIERES,
  title={FRONTIER Executive Screen: a brief executive battery to differentiate frontotemporal dementia and Alzheimer's disease},
  author={Felicity V. C. Leslie and David Foxe and Naomi Daveson and E. Flannagan and John R. Hodges and Olivier Piguet},
  journal={Journal of Neurology, Neurosurgery \& Psychiatry},
  year={2015},
  volume={87},
  pages={831 - 835}
}
Background and objective Executive dysfunctions are a key clinical feature of behavioural-variant frontotemporal dementia (bvFTD). Such deficits are also found in Alzheimer's disease (AD), making the differentiation between these two diseases difficult at times, particularly in the absence of extensive cognitive assessments. To address this issue, we developed the FRONTIER Executive Screen (FES), which combines three abbreviated measures of verbal fluency, inhibitory control and working memory… Expand
View on BMJ
sydney.edu.au
20 Citations
Highly Influential Citations
1
Background Citations
3
Methods Citations
2

20 Citations

Citation Type

Citation Type

The Behavioral Dyscontrol Scale in the differential diagnosis of behavioral variant of frontotemporal dementia and Alzheimer disease
TLDR
The Behavioral Dyscontrol Scale has good psychometric prosperities; is easy to administer and score; is well tolerated by geriatric patients; and is useful diagnostically for discriminating bvFTD from AD, yielding good to excellent sensitivity and specificity values. Expand
Disinhibition in Frontotemporal Dementia and Alzheimer’s Disease: A Neuropsychological and Behavioural Investigation
TLDR
The results highlight the current limits of cognitive measures of inhibitory control for the differential diagnosis between bvFTD and AD, whereas questionnaire information appears more reliable and in line with clinical diagnostics. Expand
Combined Socio-Behavioral Evaluation Improves the Differential Diagnosis Between the Behavioral Variant of Frontotemporal Dementia and Alzheimer's Disease: In Search of Neuropsychological Markers.
TLDR
Statistical comparison between patient groups proved social cognition and episodic memory impairments as main cognitive signatures of bvFTD and AD neuropsychological profiles, respectively. Expand
Assessing Executive Dysfunction in Neurodegenerative Disorders: A Critical Review of Brief Neuropsychological Tools
TLDR
This review critically discusses the four screening tools of EF currently available in the literature: Executive Interview-25 (EXIT 25), Frontal Assessment Battery (FAB), INECO Frontal Screening (IFS), and FRONTIER Executive Screen (FES). Expand
Alzheimer's Disease or Behavioral Variant Frontotemporal Dementia? Review of Key Points Toward an Accurate Clinical and Neuropsychological Diagnosis.
TLDR
The main differences at the clinical, neuropsychological, and behavioral levels are summarized in an attempt to suggest which aspects would facilitate an adequate diagnosis in a clinical setting, especially in Latin American and low- and middle-income countries, where the resources needed for a differential diagnosis are not always available. Expand
Psychological and Cognitive Markers of Behavioral Variant Frontotemporal Dementia–A Clinical Neuropsychologist's View on Diagnostic Criteria and Beyond
TLDR
A critical appraisal of common methods to access the behavioral and psychological symptoms as well as the cognitive alterations presented in the diagnostic criteria for Behavioral variant frontotemporal dementia is aimed at. Expand
Distinguishing Frontotemporal Dementia From Alzheimer Disease Through Everyday Function Profiles: Trajectories of Change
TLDR
Different patterns of functioning at baseline and trajectories of change in behavioral variant frontotemporal dementia (bvFTD) and Alzheimer disease (AD) are explored, showing a significant effect of syndrome and time on functioning, and evidence of interaction between Syndrome and time. Expand
Recommendations to distinguish behavioural variant frontotemporal dementia from psychiatric disorders.
TLDR
The goal of the present paper was to review the existing literature on the diagnosis of bvFTD and its differential diagnosis with primary psychiatric disorders to provide consensus recommendations on the clinical assessment and clarify the role of 18F-fluorodeoxyglucose PET for the exclusion of b vFTD. Expand
Mental States in Moving Shapes: Distinct Cortical and Subcortical Contributions to Theory of Mind Impairments in Dementia.
TLDR
The Frith-Happé animations are employed as a dynamic on-line assessment of mentalizing capacity with reduced incidental task demands and new insights are revealed into the mechanisms potentially mediating ToM disruption in dementia syndromes, and the cerebellum may play a more prominent role in social cognition than previously appreciated. Expand
Relating constructs of attention and working memory to social withdrawal in Alzheimer’s disease and schizophrenia: issues regarding paradigm selection
TLDR
This review represents the output of the collaborative group “PRISM”, tasked with considering assay choices for assessment of attention and working memory in a transdiagnostic cohort of Alzheimer's disease and schizophrenia patients exhibiting symptomatic spectra of social withdrawal. Expand
...
1
2
...

References

SHOWING 1-10 OF 40 REFERENCES
Dissociable executive functions in behavioral variant frontotemporal and Alzheimer dementias
TLDR
Executive function assessment can support bvFTD diagnosis when measures are carefully selected to emphasize frontally specific functions. Expand
The Frontal Assessment Battery Does Not Differentiate Frontotemporal Dementia from Alzheimer’s Disease
TLDR
The Frontal Assessment Battery does not differentiate patients with AD from those with FTD, like all other executive tests, however, it may be useful in the examination of executive function in AD, FTD and several other pathological conditions. Expand
Neuropsychological deficits in frontotemporal dementia and Alzheimer’s disease: a meta-analytic review
TLDR
Given the large overlap in the test performance of persons diagnosed with AD and FTD, cognitive tests should be used cautiously and in conjunction with a medical history, behavioural observations, imaging and information from relatives when making differential diagnoses. Expand
Bedside assessment of frontal degeneration: distinguishing Alzheimer's disease from non-Alzheimer's cortical dementia.
TLDR
Two instruments, the Executive Interview (EXIT) and the Qualitative Evaluation of Dementia (QED), that are useful in the evaluation of frontal system failure are discussed and mapping of EXIT scores against MMSE (errors) scores revealed that AD and FTD follow very different regression lines. Expand
Orbitofrontal Dysfunction Discriminates Behavioral Variant Frontotemporal Dementia from Alzheimer’s Disease
TLDR
A combination of OFC and disinhibition measures appears to be a powerful diagnostic tool in differentiating bvFTD from AD patients in this preliminary study. Expand
Working memory, attention, and executive function in Alzheimer’s disease and frontotemporal dementia
TLDR
A comparison of working memory, attention and executive test performance in patients with AD and frontotemporal dementia shows characteristic frontal lobe abnormalities in FTD and temporoparietal change in typical-AD, highlighting the importance of the posterior hemispheres in working memory. Expand
INECO Frontal Screening (IFS): A brief, sensitive, and specific tool to assess executive functions in dementia–CORRECTED VERSION
TLDR
The IFS is a brief, sensitive, and specific tool for the detection of executive dysfunction associated with neurodegenerative diseases and may be helpful in the differential diagnosis of FTD and AD. Expand
Clinical Utility of Short Social Cognitive Tests in Early Differentiation of Behavioral Variant Frontotemporal Dementia from Alzheimer's Disease
TLDR
The results suggest that it may indeed be relevant to include short and easily administered measures of social cognition in the differential diagnosis of early bvFTD and AD. Expand
Examining Executive Dysfunction with the Institute of Cognitive Neurology (INECO) Frontal Screening (IFS): normative values from a healthy sample and clinical utility in Alzheimer's disease.
TLDR
The IFS is useful to detect executive dysfunction in AD, showing good discriminant and concurrent validities and age and education should be taken into account when interpreting performance on the IFS. Expand
Executive function in progressive and nonprogressive behavioral variant frontotemporal dementia
TLDR
Behavioral variant frontotemporal dementia (bv-FTD) patients who progress over time are typically impaired on executive tasks at first presentation, although an important minority of true FTD patients perform normally. Expand
...
1
2
3
4
...